Relationship of family history and outcome after breast conservation therapy in women with ductal carcinoma in situ of the breast
Identifieur interne : 00A516 ( Main/Exploration ); précédent : 00A515; suivant : 00A517Relationship of family history and outcome after breast conservation therapy in women with ductal carcinoma in situ of the breast
Auteurs : Eleanor E. R Harris [États-Unis] ; Delray J. Schultz [États-Unis] ; Christopher A. Peters [États-Unis] ; Lawrence J. Solin [États-Unis]Source :
- International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 2000.
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Abstract
Purpose: The purpose of this study was to evaluate the relationship between a family history of breast or ovarian cancer and outcome after breast-conserving surgery and radiation in women presenting with an initial diagnosis of ductal carcinoma in situ (DCIS) of the breast. Methods and Materials: A total of 146 consecutive women with a pathologic diagnosis of ductal carcinoma in situ as their first diagnosis of any breast cancer were identified; 28 (19%) had a positive family history of breast or ovarian cancer in a first-degree relative, 27 (19%) had a positive family history in a second-degree relative, and 91 (62%) had no family history. Pathologic, clinical, and treatment factors, and clinical outcomes for each family history group were compared. Cosmesis and complications were recorded at each follow-up. Patients were treated between 1978 and 1995, and the median follow-up was 7.1 years. Results: Patients with a positive family history in a first- or second-degree relative each had an 8% incidence of local failure at 10 years, while the negative family history group demonstrated a 16% local failure rate (p = 0.33). Overall survival at 10 years for patients with a positive family history in a first- or second-degree relative was 100% and for those with a negative family history was 91% (p = 0.08). The negative family history group had a higher median age that may account for the difference in overall survival. Cause-specific survival (CSS) was 97%, 100%, and 99%, respectively, at 10 years (p = 0.25). There were no differences in the cosmetic results or complication rates between women with a positive or negative family history. Conclusion: We have shown that a family history of breast and/or ovarian cancer is not associated with an adverse outcome for women treated with breast conservation therapy for DCIS. Local recurrence, cause-specific survival, overall survival, cosmesis, and complication rates were comparable to that of similarly treated women with negative family histories. Therefore, a positive family history is not a contraindication for breast conservation therapy in women with DCIS.
Url:
DOI: 10.1016/S0360-3016(00)00726-4
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R" last="Harris">Eleanor E. R Harris</name><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Department of Radiation Oncology, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Schultz, Delray J" sort="Schultz, Delray J" uniqKey="Schultz D" first="Delray J" last="Schultz">Delray J. Schultz</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millersville University, Department of Mathematics, Millersville, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Peters, Christopher A" sort="Peters, Christopher A" uniqKey="Peters C" first="Christopher A" last="Peters">Christopher A. Peters</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pennsylvania, Department of Radiation Oncology, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Solin, Lawrence J" sort="Solin, Lawrence J" uniqKey="Solin L" first="Lawrence J" last="Solin">Lawrence J. Solin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millersville University, Department of Mathematics, Millersville, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Radiation Oncology, Biology, Physics</title><title level="j" type="abbrev">ROB</title><idno type="ISSN">0360-3016</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">48</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="933">933</biblScope><biblScope unit="page" to="941">941</biblScope></imprint><idno type="ISSN">0360-3016</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-3016</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast cancer</term><term>Breast-conserving therapy</term><term>Ductal carcinoma in situ</term><term>Family history</term><term>Local recurrence</term><term>Radiation therapy</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: The purpose of this study was to evaluate the relationship between a family history of breast or ovarian cancer and outcome after breast-conserving surgery and radiation in women presenting with an initial diagnosis of ductal carcinoma in situ (DCIS) of the breast. Methods and Materials: A total of 146 consecutive women with a pathologic diagnosis of ductal carcinoma in situ as their first diagnosis of any breast cancer were identified; 28 (19%) had a positive family history of breast or ovarian cancer in a first-degree relative, 27 (19%) had a positive family history in a second-degree relative, and 91 (62%) had no family history. Pathologic, clinical, and treatment factors, and clinical outcomes for each family history group were compared. Cosmesis and complications were recorded at each follow-up. Patients were treated between 1978 and 1995, and the median follow-up was 7.1 years. Results: Patients with a positive family history in a first- or second-degree relative each had an 8% incidence of local failure at 10 years, while the negative family history group demonstrated a 16% local failure rate (p = 0.33). Overall survival at 10 years for patients with a positive family history in a first- or second-degree relative was 100% and for those with a negative family history was 91% (p = 0.08). The negative family history group had a higher median age that may account for the difference in overall survival. Cause-specific survival (CSS) was 97%, 100%, and 99%, respectively, at 10 years (p = 0.25). There were no differences in the cosmetic results or complication rates between women with a positive or negative family history. Conclusion: We have shown that a family history of breast and/or ovarian cancer is not associated with an adverse outcome for women treated with breast conservation therapy for DCIS. Local recurrence, cause-specific survival, overall survival, cosmesis, and complication rates were comparable to that of similarly treated women with negative family histories. Therefore, a positive family history is not a contraindication for breast conservation therapy in women with DCIS.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Harris, Eleanor E R" sort="Harris, Eleanor E R" uniqKey="Harris E" first="Eleanor E. R" last="Harris">Eleanor E. R Harris</name></noRegion><name sortKey="Harris, Eleanor E R" sort="Harris, Eleanor E R" uniqKey="Harris E" first="Eleanor E. R" last="Harris">Eleanor E. R Harris</name><name sortKey="Peters, Christopher A" sort="Peters, Christopher A" uniqKey="Peters C" first="Christopher A" last="Peters">Christopher A. Peters</name><name sortKey="Schultz, Delray J" sort="Schultz, Delray J" uniqKey="Schultz D" first="Delray J" last="Schultz">Delray J. Schultz</name><name sortKey="Solin, Lawrence J" sort="Solin, Lawrence J" uniqKey="Solin L" first="Lawrence J" last="Solin">Lawrence J. 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